(S)-usnate reductase

(S)-usnate reductase
Identifiers
EC no.1.1.1.199
CAS no.77237-99-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, (S)-usnate reductase (EC 1.1.1.199) is an enzyme that catalyzes the chemical reaction

2D representation of the chemical structure of Q27121480.
(S)-usnic acid precursor
+ NAD+
 
 
 
H+
Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right
 
H+
 
2D representation of the chemical structure of Q27105250.
(S)-usnic acid
+ NADH
 

The enzyme converts the precursor (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one into (S)-usnic acid using oxidised nicotinamide adenine dinucleotide (NAD+) as cofactor and forming an ether bond.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming). This enzyme is also called L-usnic acid dehydrogenase.

References

  1. ^ Enzyme 1.1.1.199 at KEGG Pathway Database.
  2. ^ Barbini N, Gorini G, Ferrucci L, Biggeri A (2005). "[Analysis of arterial hypertension and work in the epidemiologic study "Aging, Health and Work"]". Epidemiol. Prev. 29 (3–4): 160–165. PMID 16454408.


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