Berberine reductase

berberine reductase
Identifiers
EC no.1.5.1.31
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction

2D representation of the chemical structure of Q27102853.
(R)-canadine
+ 2 NADP+
 
 
 
2 H+
Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right
 
2 H+
 
2D representation of the chemical structure of berberine .
berberine
+ 2 NADPH
 

The two substrates of this enzyme are (R)-canadine and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are berberine, reduced NADPH, and two protons.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.

References

  1. ^ Bauer W, Zenk MH (1991). "Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro". Tetrahedron Lett. 32 (4): 487–490. doi:10.1016/S0040-4039(00)79475-5.
  2. ^ Enzyme 1.5.1.31 at KEGG Pathway Database.
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