Nucleoside oxidase

Nucleoside oxidase
Identifiers
EC no.1.1.3.28
CAS no.82599-71-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Nucleoside oxidase (EC 1.1.3.28) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase.[1][2] This enzyme catalyses the following two chemical reactions

2D representation of the chemical structure of inosine.
Two inosine
 
O2
2 H2O
Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom left
O2
2 H2O
 
2D representation of the chemical structure of Q27103123.
Two 5'-dehydroinosine
2D representation of the chemical structure of Q27103123.
Two 5'-dehydroinosine
 
O2
 
Reversible left-right reaction arrow with minor forward substrate(s) from top left and minor reverse product(s) to bottom left
O2
 
 
2D representation of the chemical structure of Q27102495.
Two 9-riburonosylhypoxanthine

As a result, inosine is converted to 9-riburonosylhypoxanthine. This enzyme can use other purine and pyrimidine nucleosides (as well as 2'-deoxynucleosides) as substrates.[3]

References

  1. ^ Isono Y, Sudo T, Hoshino M (1989). "Purification and reaction of a new enzyme, nucleoside oxidase". Agric. Biol. Chem. 53 (6): 1663–1669. doi:10.1271/bbb1961.53.1663.
  2. ^ Isono Y, Sudo T, Hoshino M (1989). "Properties of a new enzyme, nucleoside oxidase, from Pseudomonas maltophilia LB-86". Agric. Biol. Chem. 53 (6): 1671–1677. doi:10.1271/bbb1961.53.1671.
  3. ^ Enzyme 1.1.3.28 at KEGG Pathway Database.
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