Propynyl (drug)

Propynyl
Clinical data
Other namesPROPYNYL; 4-Propynyloxy-3,5-dimethoxyphenethylamine; Propynylmescaline; Propynylscaline
Routes of
administration		Oral[1]
ATC code
  • None
Pharmacokinetic data
Duration of action8–12 hours[1]
Identifiers
  • 2-{3,5-dimethoxy-4-[(prop-2-yn-1-yl)oxy]phenyl}ethan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17NO3
Molar mass235.283 g·mol−1
3D model (JSmol)
  • COc1cc(cc(OC)c1OCC#C)CCN
  • InChI=1S/C13H17NO3/c1-4-7-17-13-11(15-2)8-10(5-6-14)9-12(13)16-3/h1,8-9H,5-7,14H2,2-3H3 checkY
  • Key:KNIWBMMJSJHUJB-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Propynyl, also known as 4-propynyloxy-3,5-dimethoxyphenethylamine or as propynylscaline, is a lesser-known drug of the scaline family. It is closely related in structure to mescaline. Propynyl was first synthesized by Alexander Shulgin. In his book PiHKAL, the minimum dosage is listed as 80 mg, and the duration listed as 8–12 hours.[1] Propynyl produces a body load and few to no mental effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of propynyl. It is not a controlled substance in Canada as of 2025.[2]

See also

References

  1. ^ a b c Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. Propynyl entry
  2. ^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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